A review on scope of immuno-modulatory drugs in Ayurveda for prevention and treatment of Covid-19
DOI:
https://doi.org/10.14719/pst.2020.7.3.831Keywords:
SARS-CoV-2 Rasayana dravyas Ashwagandha Suvarna prashana AYUSH–64, AYUSH–64, Suvarna prashana, Ashwagandha, Rasayana dravyas, SARS-CoV-2Abstract
The Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome Coronavirus-2 (SARS CoV-2) infection attacking mainly on the immune system of a body. It is a potentially fatal disease that is of public health and economy concern globally. In December 2019, COVID-19 outbreak occurred in Wuhan city, Hubei Province, China furthermore spread worldwide. Research is underway in many countries to develop effective vaccines and drugs for the COVID-19. In Ayurveda, Acharya Charaka explained the concept of an epidemic condition in Janapadodhwans Adhayay and combating of these diseases is to be done by Panchakarma (five procedures of purification), Rasayana Chikitsa (immune-modulators therapy) and Sadvritta (good conduct). Rasayan dravyas (immuno modulators drugs) of Ayurveda can be used for health promotion, immune-modulation, prevention and reduce disease burden from COVID-19. Drugs such as Ashwagandha (Withania somnifera (L.) Dunal), Guduchi (Tinospora cordifoloia (Willd.) Miers), Amalaki (Phyllanthus emblica L.), Mulethi (Glycyrrhiza glabra L.), Shatavari (Asparagus racemosus Willd), Chireta (Andrographis paniculata (Burm.f.) Nees), Tulsi (Ocimum sanctum L.) Punarnava (Boerhaavia diffusa L.) and Pippali ((Piper longum L.) For symptom management of COVID-19 like illness Agastya Haritaki, Anutaila, AYUSH–64 can be used. Scientific research on these drugs may reveal the new approach for the prevention and management of COVID-19. The main aim of this article is to review research which has already conducted and currently being carried out on the herbal plant for their immunomodulation property which have a possible application in the prevention and treatment of COVID-19.
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References
1. Civljak, R., Markotic, A., & Kuzman, I. The third coronavirus epidemic in the third millennium: what's next? Croatian medical journal. 2020; 61(1): 1–4. https://doi.org/10.3325/cmj.2020.61.1
2. Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Bio Med [Internet]. 2020Mar.19 [cited 2020Jul.13]; 91(1):157-60 https://doi.org/10.23750/abm.v91i1.9397
3. Sahasranaman A, Kumar N. Network structure of COVID-19 spread and the lacuna in India's testing strategy. Available at SSRN 3558548. 2020. https://doi.org/10.2139/ssrn.3558548
4. Ministry of AYUSH. Ayurveda’s immunity boosting measures for self care during COVID19. 2020, available from https://www.mohfw.gov.in/pdf/ImmunityBoostingAYUSHAdvisory.pdf
5. Pandey Gangasahay, editor. Pt. Kashinath Sastri Vidhyotini Hindi commentarator of Charaka Samhita of Agnivesha- 1st volume, Viman Sthan chapter 3 verse 8. Varanasi: Chaukumba Sanskrit Sansthan; 2006. p. 445
6. Satyapal Singh, P.S. Byadgi, J.S. Tripathi and N.P. Rai. Clinical appraisal of immunomodulators in Ayurveda in the light of recent pharmacological advances. World J. Pharm. Res. 2015; 4 (4):678-92.
7. Chauhan VP, Dutt B, Vyas M, Gupta SK. Effect of immune-modulators (Rasayana Dravya) in Janapadodhwansa WSR to COVID-19. J Ayu Herb.2020; 6(1):26- 29.
8. Kumar VP, Kuttan R, Kuttan G. Effect of ‘‘Rasayanas’’ a herbal drug preparation on cell mediated immune responses in tumor bearing mice. Indian J Exp. Biol. 1999; 37(1):23-6.
9. Vaidya yadavji Trikamji Acharya (Ed.), Shri Dalhanacharaya Nibandhasamgraha commentarator of Sushruta Samhita, Nidan Sthan Kushthadhyaya (5/33-34), Chaukumba Sanskrit Sansthan, Varanasi (2009), p. 211.
10. Agnivesha, Charaka Samhita elaborated by Charaka & Drudhabala with Ayurveda-Deepika Commentary by Chakrarapanidatta, edited by Vaidya Jadavaji Trikamji Acharya, Varanasi, Chaukhambha Surbharati Prakashan, Reprinted 2011, Vimana sthana chapter 6, verse no.3, page no. 252.
11. Tripathi JS, Singh RH. The concept and practice of immunomodulation in Ayurveda and the role of Rasayanas as immunomodulators. Ancient Science of Life. 1999; 19(1-2):59.
12. Nikhat S, Fazil M. Overview of COVID-19; its prevention and management in the light of Unani medicine. Science of the total Environment. 2020. Vol 728:138859. https://doi.org/10.1016/j.scitotenv.2020.138859
13. Yang H, Bartlam M, Rao Z. Drug design targeting the main protease, the Achilles' heel of coronaviruses. Current pharmaceutical design. 2006; 12(35):4573-90. https://doi.org/10.2174/138161206779010369
14. Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive care medicine. 2020; 46(4):586-90. https://doi.org/10.1007/s00134-020-05985-9
15. Zhao Y, Zhao Z, Wang Y, Zhou Y, Ma Y, Zuo W. Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan COVID-19. BioRxiv 2020.01.26.919985. https://doi.org/10.1101/2020.01.26.919985
16. Guo YR, Cao QD, Hong ZS, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak–an update on the status. Mil Med Res. 2020; 7(1):11. https://doi.org/10.1186/s40779-020-00240-0
17. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet.2020; 395(10223):497-506.https://doi.org/10.1016/S0140-6736(20)30183-5.
18. Tang YW, Schmitz JE, Persing DH, Stratton CW. Laboratory diagnosis of COVID-19: current issues and challenges. Journal of clinical microbiology. 2020; 58(6); 12-20. https://doi.org/10.1128/JCM.00512-20
19. Padhi A, Kumar S, Gupta E, Saxena SK. Laboratory Diagnosis of Novel Coronavirus Disease 2019 (COVID-19) Infection. In Coronavirus Disease 2019 (COVID-19) 2020 (pp. 95-107). Springer, Singapore. https://doi.org/10.1007/978-981-15-4814-7_9
20. Tsang OT, Chau TN, Choi KW, Tso EY, Lim W, Chiu MC, et al. Severe acute respiratory syndrome: relapse? Hospital infection? Emerging infectious diseases. 2003; 9(9):1180-81 https://doi.org/10.3201/eid0909.030395
21. Patwardhan B, Chavan-Gautam P, Gautam M, Tillu G, Chopra A, Gairola S, et al. Ayurveda rasayana in prophylaxis of COVID-19. Curr Sci. 2020; 118:1158-60.
22. Kindler E, Thiel V, Weber F. Interaction of SARS and MERS coronaviruses with the antiviral interferon response. Adv Virus Res. 2016; Vol. 96: 219-243. https://doi.org/10.1016/bs.aivir.2016.08.006
23. Wong CK, Lam CW, Wu AK, Ip WK, Lee NL, Chan IH et al. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clinical & Experimental Immunology. 2004; 136 (1):95-103. https://doi.org/10.1111/j.1365-2249.2004.02415.x
24. Osakwe CE, Bleotu C, Chifiriuc MC, Grancea C, Otelea D, Paraschiv S, et al. TH1/TH2 cytokine levels as an indicator for disease progression in human immunodeficiency virus type 1 infection and response to antiretroviral therapy. Roum Arch Microbiol Immunol. 2010;69(1):24-34
25. Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, Liu C, Yang C. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020; 87: 18-22. https://doi.org/10.1016/j.bbi.2020.03.031
26. Jean SS, Lee PI, Hsueh PR. Treatment options for COVID-19: The reality and challenges. J. Microbiol. Immunol. Infect. 2020; 43(3) 436-443. https://doi.org/10.1016/j.jmii.2020.03.034
27. Hashemi SR, Davoodi H. Herbal plants as new immuno-stimulator in poultry industry: a review. Asian Journal of Animal and Veterinary Advances. 2012; 7(2):105-16. https://doi.org/10.3923/ajava.2012.105.116.
28. Mahima , Anu Rahal, Rajib Deb, Shyma K. Latheef, Hari Abdul Samad, et al. Immunomodulatory and Therapeutic Potentials of Herbal, Traditional/Indigenous and Ethnoveterinary Medicines. Pakistan Journal of Biological Sciences. 2012; 15(16):754-74. https://doi.org/10.3923/pjbs.2012.754.774
29. Tiwari R, Chakraborty S, Saminathan M, Dhama K, Singh SV. Ashwagandha (Withania somnifera): Role in safeguarding health, immunomodulatory effects, combating infections and therapeutic applications: A review. Journal of Biological Sciences. 2014; 14 (2):77-94. https://doi.org/10.3923/jbs.2014.77.94
30. Gautam M, Diwanay SS, Gairola S, Shinde YS, Jadhav SS, Patwardhan BK. Immune response modulation to DPT vaccine by aqueous extract of Withania somnifera in experimental system. International immunopharmacology. 2004; 4 (6):841-9. https://doi.org/10.1016/j.intimp.2004.03.005
31. Kumar R, Rai J, Kajal NC, Devi P. Comparative study of effect of Withania somnifera as an adjuvant to DOTS in patients of newly diagnosed sputum smear positive pulmonary tuberculosis. Indian Journal of Tuberculosis. 2018; 65 (3):246-51. https://doi.org/10.1016/j.ijtb.2017.05.005.
32. Akhtar S. Use of Tinospora cordifolia in HIV infection. Indian Journal of Pharmacology. 2010; 42(1):57. https://doi.org/10.4103/0253-7613.62402.
33. Upadhyaya R, Pandey RP, Sharma V, Verma Anita K. Assessment of the multifaceted immunomodulatory potential of the aqueous extract of Tinospora cordifolia. Research Journal of Chemical Sciences. 2011; 1(6): 71-79.
34. Mainzen Prince PS, Padmanabhan M, Menon VP. Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan?induced diabetic liver and kidney. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2004; 18 (9):785-7. https://doi.org/10.1002/ptr.1567
35. Aranha I, Clement F, Venkatesh YP. Immunostimulatory properties of the major protein from the stem of the Ayurvedic medicinal herb, guduchi (Tinospora cordifolia). Journal of ethnopharmacology. 2012; 139 (2):366-72. https://doi.org/10.1016/j.jep.2011.11.013
36. Ministry of AYUSH, Advisory from ministry of Ayush for meeting the challenge arising out of spread of corona virus (COVID-19) in India. 2020. available from: https://www.ayush.gov.in/docs/125.pdf.
37. Pandey Gangasahay, editor. Pt. Kashinath Sastri Vidhyotini Hindi commentarator of Charaka Samhita of Agnivesha- 1st volume, Sutra Sthan chapter 25 verse 40. Varanasi: Chaukumba Sanskrit Sansthan; 2006. p. 201
38. Pandey Gangasahay, editor. Pt. Kashinath Sastri Vidhyotini Hindi commentarator of Charaka Samhita of Agnivesha- 1st volume, Sutra Sthan chapter 4 verse 11-13. Varanasi: Chaukumba Sanskrit Sansthan; 2006. p. 88
39. Sharma R, Martins N, Kuca K, Chaudhary A, Kabra A, Rao MM, Prajapati PK. Chyawanprash: a traditional Indian bioactive health supplement. Biomolecules. 2019; 9 (5):161. https://doi.org/10.3390/biom9050161.
40. Saini A, Sharma S, Chhibber S. Protective efficacy of Emblica officinalis against Klebsiella pneumoniae induced pneumonia in mice. Indian Journal of Medical Research. 2008; 128 (2):188-93.
41. Tsuchiya H, Sato M, Miyazaki T, Fujiwara S, Tanigaki S, Ohyama M, Tanaka T, Iinuma M. Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus. Journal of ethnopharmacology. 1996; 50 (1):27-34. https://doi.org/10.1016/0378-8741(96)85514-0.
42. Repine JE, Bast AA, Lankhorst ID, Oxidative Stress Study Group. Oxidative stress in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine. 1997; 156 (2):341-57. https://doi.org/10.1164/ajrccm.156.2.9611013.
43. Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr HW. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. The Lancet. 2003; 361 (9374):2045-6. https://doi.org/10.1016/S0140-6736(03)13615-X.
44. Wang L, Yang R, Yuan B, Liu Y, Liu C. The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. Acta Pharmaceutica Sinica B. 2015; 5 (4):310-5. https://doi.org/10.1016/j.apsb.2015.05.005.
45. Akamatsu H, Komura J, Asada Y, Niwa Y. Mechanism of anti-inflammatory action of glycyrrhizin: effect on neutrophil functions including reactive oxygen species generation. Planta medica. 1991; 57(02):119-21. https://doi.org/10.1055/s-2006-960045
46. Dahanukar S, Thatte U, Pai N, Mose PB, Karandikar SM. Protective effect of Asparagus racemosus against induced abdominal sepsis. Indian Drugs. 1986; 24(3):125-8.
47. Gautam M, Diwanay S, Gairola S, Shinde Y, Patki P, Patwardhan B. Immunoadjuvant potential of Asparagus racemosus aqueous extract in experimental system. Journal of ethnopharmacology. 2004; 91 (2-3):251-5. https://doi.org/10.1016/j.jep.2003.12.023
48. Naik SR, Hule A. Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata. Planta medica. 2009 Jun; 75 (08):785-91. https://doi.org/10.1055/s-0029-1185398
49. Carr RR, Nahata MC. Complementary and alternative medicine for upper-respiratory-tract infection in children. American journal of health-system pharmacy. 2006; 63(1):33-9. https://doi.org/10.2146/ajhp040613
50. Cohen MM. Tulsi-Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and integrative medicine. 2014; 5 (4):251-59. https://doi.org/10.4103/0975-9476.146554.
51. Pattanayak P, Behera P, Das D, Panda SK. Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacognosy reviews. 2010; 4 (7):95-105.https://doi.org/10.4103/0973-7847.65323.
52. Mondal S, Varma S, Bamola VD, Naik SN, Mirdha BR, Padhi MM, Mehta N, Mahapatra SC. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. Journal of ethnopharmacology. 2011; 136 (3):452-6. https://doi.org/10.1016/j.jep.2011.05.012.
53. Ravi V, Parida S, Desai A, Chandramuki A, Gourie?Devi M, Grau GE. Correlation of tumor necrosis factor levels in the serum and cerebrospinal fluid with clinical outcome in Japanese encephalitis patients. Journal of medical virology. 1997; 51(2):132-6. https://doi.org/10.1002/(SICI)1096-9071(199702)51:2<132::AID-JMV8>3.0.CO;2-8.
54. Sangeetha P, Poornamathy JJ. In vitro assessment of anti-inflammatory activity of Ocimum sanctum (karunthulasi leaves). Int Pharma Bio Sci. 2015; 6: B1387-91.
55. Mungantiwar AA, Nair AM, Shinde UA, Dikshit VJ, Saraf MN, Thakur VS, et al. Studies on the immunomodulatory effects of Boerhaavia diffusa alkaloid fraction. Journal of Ethnopharmacology. 1999; 65 (2):125-31. https://doi.org/10.1016/S0378-8741(98)00153-6.
56. Manu KA, Kuttan G. Immunomodulatory activities of Punarnavine, an alkaloid from Boerhaavia diffusa. Immunopharmacology and Immunotoxicology. 2009; 31 (3):377-87. https://doi.org/10.1080/08923970802702036.
57. Awasthi LP, Verma HN. Boerhaavia diffusa–A wild herb with potent biological and antimicrobial properties. Asian Agri-History. 2006; 10 (1):55-68.
58. Sunila ES, Kuttan G. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. Journal of ethnopharmacology. 2004; 90 (2-3):339-46. https://doi.org/10.1016/j.jep.2003.10.016.
59. Khushbu C, Roshni S, Anar P, Carol M, Mayuree P. Phytochemical and therapeutic potential of Piper longum Linn a review. International journal of research in Ayurveda and pharmacy. 2011; 2 (1):157-61.
60. Jyothy KB, Sheshagiri S, Patel KS, Rajagopala S. A critical appraisal on Swarnaprashana in children. Ayu. 2014; 35(4):361. https://doi.org/10.4103/0974-8520.158978.
61. Raj GR, Shailaja U, Sagar K, Viswaroopan D, Kumar SN. Swarnaprashana to Swarnamritaprashana: experience inspired modification through ages. International journal of pharmaceutical sciences and research. 2017; 8 (11):4546-50.
62. Bajaj S, Ahmad I, Raisuddin S, Vohora SB. Augmentation of non-specific immunity in mice by gold preparations used in traditional systems of medicine. Indian J Med Res Indian. 2001; 113:192-96.
63. Ministry of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy (AYUSH), Government of India, 2020, available from: https://health.ncog.gov.in/ayush-covid-dashbaord
64. Central Council for Research in Ayurvedic Sciences (CCRAS), 2014, available from: http://www.ccras.nic.in/sites/default/files/viewpdf/IEC_Communication/Ayush%2064.pdf.
65. Pandey Gangasahay, editor. Pt. Kashinath Sastri Vidhyotini Hindi commentarator of Charaka Samhita of Agnivesha- 2nd volume, Chikitsa Sthan chapter 18 verse 57-60. Varanasi: Chaukumba Sanskrit Sansthan; 2006. p. 237-238
66. Pt Harisadashiva shastri paradakara (Ed.), Sarvang sundar commentary by Arundatta and Ayurveda rasayan commentary by Hemadri of Astang Hridya of Vagbhata, Sutra Sthan Adhayay chapter 20 verse 38–39, Chaukhambha Surbharati Prakashan Reprinted, Varanasi (2011), p. 293-94.
2. Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Bio Med [Internet]. 2020Mar.19 [cited 2020Jul.13]; 91(1):157-60 https://doi.org/10.23750/abm.v91i1.9397
3. Sahasranaman A, Kumar N. Network structure of COVID-19 spread and the lacuna in India's testing strategy. Available at SSRN 3558548. 2020. https://doi.org/10.2139/ssrn.3558548
4. Ministry of AYUSH. Ayurveda’s immunity boosting measures for self care during COVID19. 2020, available from https://www.mohfw.gov.in/pdf/ImmunityBoostingAYUSHAdvisory.pdf
5. Pandey Gangasahay, editor. Pt. Kashinath Sastri Vidhyotini Hindi commentarator of Charaka Samhita of Agnivesha- 1st volume, Viman Sthan chapter 3 verse 8. Varanasi: Chaukumba Sanskrit Sansthan; 2006. p. 445
6. Satyapal Singh, P.S. Byadgi, J.S. Tripathi and N.P. Rai. Clinical appraisal of immunomodulators in Ayurveda in the light of recent pharmacological advances. World J. Pharm. Res. 2015; 4 (4):678-92.
7. Chauhan VP, Dutt B, Vyas M, Gupta SK. Effect of immune-modulators (Rasayana Dravya) in Janapadodhwansa WSR to COVID-19. J Ayu Herb.2020; 6(1):26- 29.
8. Kumar VP, Kuttan R, Kuttan G. Effect of ‘‘Rasayanas’’ a herbal drug preparation on cell mediated immune responses in tumor bearing mice. Indian J Exp. Biol. 1999; 37(1):23-6.
9. Vaidya yadavji Trikamji Acharya (Ed.), Shri Dalhanacharaya Nibandhasamgraha commentarator of Sushruta Samhita, Nidan Sthan Kushthadhyaya (5/33-34), Chaukumba Sanskrit Sansthan, Varanasi (2009), p. 211.
10. Agnivesha, Charaka Samhita elaborated by Charaka & Drudhabala with Ayurveda-Deepika Commentary by Chakrarapanidatta, edited by Vaidya Jadavaji Trikamji Acharya, Varanasi, Chaukhambha Surbharati Prakashan, Reprinted 2011, Vimana sthana chapter 6, verse no.3, page no. 252.
11. Tripathi JS, Singh RH. The concept and practice of immunomodulation in Ayurveda and the role of Rasayanas as immunomodulators. Ancient Science of Life. 1999; 19(1-2):59.
12. Nikhat S, Fazil M. Overview of COVID-19; its prevention and management in the light of Unani medicine. Science of the total Environment. 2020. Vol 728:138859. https://doi.org/10.1016/j.scitotenv.2020.138859
13. Yang H, Bartlam M, Rao Z. Drug design targeting the main protease, the Achilles' heel of coronaviruses. Current pharmaceutical design. 2006; 12(35):4573-90. https://doi.org/10.2174/138161206779010369
14. Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive care medicine. 2020; 46(4):586-90. https://doi.org/10.1007/s00134-020-05985-9
15. Zhao Y, Zhao Z, Wang Y, Zhou Y, Ma Y, Zuo W. Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan COVID-19. BioRxiv 2020.01.26.919985. https://doi.org/10.1101/2020.01.26.919985
16. Guo YR, Cao QD, Hong ZS, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak–an update on the status. Mil Med Res. 2020; 7(1):11. https://doi.org/10.1186/s40779-020-00240-0
17. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet.2020; 395(10223):497-506.https://doi.org/10.1016/S0140-6736(20)30183-5.
18. Tang YW, Schmitz JE, Persing DH, Stratton CW. Laboratory diagnosis of COVID-19: current issues and challenges. Journal of clinical microbiology. 2020; 58(6); 12-20. https://doi.org/10.1128/JCM.00512-20
19. Padhi A, Kumar S, Gupta E, Saxena SK. Laboratory Diagnosis of Novel Coronavirus Disease 2019 (COVID-19) Infection. In Coronavirus Disease 2019 (COVID-19) 2020 (pp. 95-107). Springer, Singapore. https://doi.org/10.1007/978-981-15-4814-7_9
20. Tsang OT, Chau TN, Choi KW, Tso EY, Lim W, Chiu MC, et al. Severe acute respiratory syndrome: relapse? Hospital infection? Emerging infectious diseases. 2003; 9(9):1180-81 https://doi.org/10.3201/eid0909.030395
21. Patwardhan B, Chavan-Gautam P, Gautam M, Tillu G, Chopra A, Gairola S, et al. Ayurveda rasayana in prophylaxis of COVID-19. Curr Sci. 2020; 118:1158-60.
22. Kindler E, Thiel V, Weber F. Interaction of SARS and MERS coronaviruses with the antiviral interferon response. Adv Virus Res. 2016; Vol. 96: 219-243. https://doi.org/10.1016/bs.aivir.2016.08.006
23. Wong CK, Lam CW, Wu AK, Ip WK, Lee NL, Chan IH et al. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clinical & Experimental Immunology. 2004; 136 (1):95-103. https://doi.org/10.1111/j.1365-2249.2004.02415.x
24. Osakwe CE, Bleotu C, Chifiriuc MC, Grancea C, Otelea D, Paraschiv S, et al. TH1/TH2 cytokine levels as an indicator for disease progression in human immunodeficiency virus type 1 infection and response to antiretroviral therapy. Roum Arch Microbiol Immunol. 2010;69(1):24-34
25. Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, Liu C, Yang C. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020; 87: 18-22. https://doi.org/10.1016/j.bbi.2020.03.031
26. Jean SS, Lee PI, Hsueh PR. Treatment options for COVID-19: The reality and challenges. J. Microbiol. Immunol. Infect. 2020; 43(3) 436-443. https://doi.org/10.1016/j.jmii.2020.03.034
27. Hashemi SR, Davoodi H. Herbal plants as new immuno-stimulator in poultry industry: a review. Asian Journal of Animal and Veterinary Advances. 2012; 7(2):105-16. https://doi.org/10.3923/ajava.2012.105.116.
28. Mahima , Anu Rahal, Rajib Deb, Shyma K. Latheef, Hari Abdul Samad, et al. Immunomodulatory and Therapeutic Potentials of Herbal, Traditional/Indigenous and Ethnoveterinary Medicines. Pakistan Journal of Biological Sciences. 2012; 15(16):754-74. https://doi.org/10.3923/pjbs.2012.754.774
29. Tiwari R, Chakraborty S, Saminathan M, Dhama K, Singh SV. Ashwagandha (Withania somnifera): Role in safeguarding health, immunomodulatory effects, combating infections and therapeutic applications: A review. Journal of Biological Sciences. 2014; 14 (2):77-94. https://doi.org/10.3923/jbs.2014.77.94
30. Gautam M, Diwanay SS, Gairola S, Shinde YS, Jadhav SS, Patwardhan BK. Immune response modulation to DPT vaccine by aqueous extract of Withania somnifera in experimental system. International immunopharmacology. 2004; 4 (6):841-9. https://doi.org/10.1016/j.intimp.2004.03.005
31. Kumar R, Rai J, Kajal NC, Devi P. Comparative study of effect of Withania somnifera as an adjuvant to DOTS in patients of newly diagnosed sputum smear positive pulmonary tuberculosis. Indian Journal of Tuberculosis. 2018; 65 (3):246-51. https://doi.org/10.1016/j.ijtb.2017.05.005.
32. Akhtar S. Use of Tinospora cordifolia in HIV infection. Indian Journal of Pharmacology. 2010; 42(1):57. https://doi.org/10.4103/0253-7613.62402.
33. Upadhyaya R, Pandey RP, Sharma V, Verma Anita K. Assessment of the multifaceted immunomodulatory potential of the aqueous extract of Tinospora cordifolia. Research Journal of Chemical Sciences. 2011; 1(6): 71-79.
34. Mainzen Prince PS, Padmanabhan M, Menon VP. Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan?induced diabetic liver and kidney. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2004; 18 (9):785-7. https://doi.org/10.1002/ptr.1567
35. Aranha I, Clement F, Venkatesh YP. Immunostimulatory properties of the major protein from the stem of the Ayurvedic medicinal herb, guduchi (Tinospora cordifolia). Journal of ethnopharmacology. 2012; 139 (2):366-72. https://doi.org/10.1016/j.jep.2011.11.013
36. Ministry of AYUSH, Advisory from ministry of Ayush for meeting the challenge arising out of spread of corona virus (COVID-19) in India. 2020. available from: https://www.ayush.gov.in/docs/125.pdf.
37. Pandey Gangasahay, editor. Pt. Kashinath Sastri Vidhyotini Hindi commentarator of Charaka Samhita of Agnivesha- 1st volume, Sutra Sthan chapter 25 verse 40. Varanasi: Chaukumba Sanskrit Sansthan; 2006. p. 201
38. Pandey Gangasahay, editor. Pt. Kashinath Sastri Vidhyotini Hindi commentarator of Charaka Samhita of Agnivesha- 1st volume, Sutra Sthan chapter 4 verse 11-13. Varanasi: Chaukumba Sanskrit Sansthan; 2006. p. 88
39. Sharma R, Martins N, Kuca K, Chaudhary A, Kabra A, Rao MM, Prajapati PK. Chyawanprash: a traditional Indian bioactive health supplement. Biomolecules. 2019; 9 (5):161. https://doi.org/10.3390/biom9050161.
40. Saini A, Sharma S, Chhibber S. Protective efficacy of Emblica officinalis against Klebsiella pneumoniae induced pneumonia in mice. Indian Journal of Medical Research. 2008; 128 (2):188-93.
41. Tsuchiya H, Sato M, Miyazaki T, Fujiwara S, Tanigaki S, Ohyama M, Tanaka T, Iinuma M. Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus. Journal of ethnopharmacology. 1996; 50 (1):27-34. https://doi.org/10.1016/0378-8741(96)85514-0.
42. Repine JE, Bast AA, Lankhorst ID, Oxidative Stress Study Group. Oxidative stress in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine. 1997; 156 (2):341-57. https://doi.org/10.1164/ajrccm.156.2.9611013.
43. Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr HW. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. The Lancet. 2003; 361 (9374):2045-6. https://doi.org/10.1016/S0140-6736(03)13615-X.
44. Wang L, Yang R, Yuan B, Liu Y, Liu C. The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. Acta Pharmaceutica Sinica B. 2015; 5 (4):310-5. https://doi.org/10.1016/j.apsb.2015.05.005.
45. Akamatsu H, Komura J, Asada Y, Niwa Y. Mechanism of anti-inflammatory action of glycyrrhizin: effect on neutrophil functions including reactive oxygen species generation. Planta medica. 1991; 57(02):119-21. https://doi.org/10.1055/s-2006-960045
46. Dahanukar S, Thatte U, Pai N, Mose PB, Karandikar SM. Protective effect of Asparagus racemosus against induced abdominal sepsis. Indian Drugs. 1986; 24(3):125-8.
47. Gautam M, Diwanay S, Gairola S, Shinde Y, Patki P, Patwardhan B. Immunoadjuvant potential of Asparagus racemosus aqueous extract in experimental system. Journal of ethnopharmacology. 2004; 91 (2-3):251-5. https://doi.org/10.1016/j.jep.2003.12.023
48. Naik SR, Hule A. Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata. Planta medica. 2009 Jun; 75 (08):785-91. https://doi.org/10.1055/s-0029-1185398
49. Carr RR, Nahata MC. Complementary and alternative medicine for upper-respiratory-tract infection in children. American journal of health-system pharmacy. 2006; 63(1):33-9. https://doi.org/10.2146/ajhp040613
50. Cohen MM. Tulsi-Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and integrative medicine. 2014; 5 (4):251-59. https://doi.org/10.4103/0975-9476.146554.
51. Pattanayak P, Behera P, Das D, Panda SK. Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacognosy reviews. 2010; 4 (7):95-105.https://doi.org/10.4103/0973-7847.65323.
52. Mondal S, Varma S, Bamola VD, Naik SN, Mirdha BR, Padhi MM, Mehta N, Mahapatra SC. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. Journal of ethnopharmacology. 2011; 136 (3):452-6. https://doi.org/10.1016/j.jep.2011.05.012.
53. Ravi V, Parida S, Desai A, Chandramuki A, Gourie?Devi M, Grau GE. Correlation of tumor necrosis factor levels in the serum and cerebrospinal fluid with clinical outcome in Japanese encephalitis patients. Journal of medical virology. 1997; 51(2):132-6. https://doi.org/10.1002/(SICI)1096-9071(199702)51:2<132::AID-JMV8>3.0.CO;2-8.
54. Sangeetha P, Poornamathy JJ. In vitro assessment of anti-inflammatory activity of Ocimum sanctum (karunthulasi leaves). Int Pharma Bio Sci. 2015; 6: B1387-91.
55. Mungantiwar AA, Nair AM, Shinde UA, Dikshit VJ, Saraf MN, Thakur VS, et al. Studies on the immunomodulatory effects of Boerhaavia diffusa alkaloid fraction. Journal of Ethnopharmacology. 1999; 65 (2):125-31. https://doi.org/10.1016/S0378-8741(98)00153-6.
56. Manu KA, Kuttan G. Immunomodulatory activities of Punarnavine, an alkaloid from Boerhaavia diffusa. Immunopharmacology and Immunotoxicology. 2009; 31 (3):377-87. https://doi.org/10.1080/08923970802702036.
57. Awasthi LP, Verma HN. Boerhaavia diffusa–A wild herb with potent biological and antimicrobial properties. Asian Agri-History. 2006; 10 (1):55-68.
58. Sunila ES, Kuttan G. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. Journal of ethnopharmacology. 2004; 90 (2-3):339-46. https://doi.org/10.1016/j.jep.2003.10.016.
59. Khushbu C, Roshni S, Anar P, Carol M, Mayuree P. Phytochemical and therapeutic potential of Piper longum Linn a review. International journal of research in Ayurveda and pharmacy. 2011; 2 (1):157-61.
60. Jyothy KB, Sheshagiri S, Patel KS, Rajagopala S. A critical appraisal on Swarnaprashana in children. Ayu. 2014; 35(4):361. https://doi.org/10.4103/0974-8520.158978.
61. Raj GR, Shailaja U, Sagar K, Viswaroopan D, Kumar SN. Swarnaprashana to Swarnamritaprashana: experience inspired modification through ages. International journal of pharmaceutical sciences and research. 2017; 8 (11):4546-50.
62. Bajaj S, Ahmad I, Raisuddin S, Vohora SB. Augmentation of non-specific immunity in mice by gold preparations used in traditional systems of medicine. Indian J Med Res Indian. 2001; 113:192-96.
63. Ministry of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy (AYUSH), Government of India, 2020, available from: https://health.ncog.gov.in/ayush-covid-dashbaord
64. Central Council for Research in Ayurvedic Sciences (CCRAS), 2014, available from: http://www.ccras.nic.in/sites/default/files/viewpdf/IEC_Communication/Ayush%2064.pdf.
65. Pandey Gangasahay, editor. Pt. Kashinath Sastri Vidhyotini Hindi commentarator of Charaka Samhita of Agnivesha- 2nd volume, Chikitsa Sthan chapter 18 verse 57-60. Varanasi: Chaukumba Sanskrit Sansthan; 2006. p. 237-238
66. Pt Harisadashiva shastri paradakara (Ed.), Sarvang sundar commentary by Arundatta and Ayurveda rasayan commentary by Hemadri of Astang Hridya of Vagbhata, Sutra Sthan Adhayay chapter 20 verse 38–39, Chaukhambha Surbharati Prakashan Reprinted, Varanasi (2011), p. 293-94.
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Niraj S, Varsha S. A review on scope of immuno-modulatory drugs in Ayurveda for prevention and treatment of Covid-19. Plant Sci. Today [Internet]. 2020 Jul. 18 [cited 2024 Apr. 18];7(3):417-23. Available from: https://www.horizonepublishing.com/journals/index.php/PST/article/view/831
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